Schamberg's disease , (also known as " progressive pigmentation dermatitis from Schamberg ", "purpura pigmentosa progressiva b " ( PPP ), and " purpura Schamberg ") are chronic skin changes found in people of all ages, usually affecting the feet. It slowly spreads throughout the body, and most often occurs in men. It's named after Jay Frank Schamberg, who described it in 1901. There is no known cure for this disease and it is not a life-threatening condition. Skin lesions can cause itching, which can be treated by applying cortisone cream. The cortisone cream will only help with the itchiness and discoloration of the skin will remain, which may cause cosmetic problems in the future. Schamberg's disease is usually asymptomatic, meaning it shows no signs of this condition, except skin discoloration. This condition is caused by a leaking blood vessel, in which the red blood cells escape near the skin surface and release the iron to the surrounding tissue. The cause of leaky capillaries is unknown.
Video Schamberg disease
Symptoms
Lesions are most common in the lower extremities, but can occur anywhere on the body, including the hands, arms, legs and even the neck. They can vary in numbers and erupt in large quantities. They consist of irregular patches of orange or brown pigments with characteristics of "cayenne pepper" spots that appear within and on the edges of old lesions. There are usually no symptoms, although there may be a slight itch, but no pain. The eruption may last for years. The pattern of the eruption changed, with a slow extension and often some cleansing of the original lesion.
Schamberg's disease, or progressive pigmented pygmy dermatosis, is a chronic color change in the skin that usually affects the feet and often spreads slowly. This disease is more common in men and can occur at any age from childhood onwards. This condition is observed throughout the world and has nothing to do with race or ethnic background.
Maps Schamberg disease
Cause
Schamberg's disease is caused by a leaky blood vessel near the surface of the skin, the capillaries, which allow the red blood cells into the skin. The red blood cells in the skin then fall out and release their iron, which is released from hemoglobin. Iron causes rust color and this causes the orange color of the rash that can be seen on the skin. The underlying cause of leaky blood vessels is unknown, but the investigators suggest that there may be some potential triggers. Some of the possible triggers include viral infection, hypersensitivity to some agents, and multiple drug interactions, such as thiamine and aspirin. Although there is no correlation with genetics, there are some cases where some people in the family have this condition.
Although the cause of capillary inflammation is unknown, certain precautions can be taken. Your doctor may prescribe medications that promote blood circulation, which can keep your blood vessels strong and healthy.
Mechanism
Schamberg's disease is a skin disorder that causes discoloration of the lower limb. It manifests in the lower extremities and gradually moves in any direction on the body. This condition is caused by leaking blood vessels near the skin surface. The cause of leaky capillaries is still unknown, but is responsible for skin discoloration. Because the blood vessels weaken, the red blood cells come out of the blood vessels, where they end up near the skin's surface. In one red blood cell, there are four heme groups and each heme group consists of one iron. Iron is responsible for helping red blood cells transfer oxygen from the lungs to the cells and carry carbon dioxide from the cells to the lungs. When the red blood cells come out of the blood vessels, the red blood cells rupture, releasing hemoglobin. Iron is released from hemoglobin and deposited onto the skin. Since iron has no place to go and can not be absorbed back into the blood, it will break. The hemosiderin iron complex is responsible for skin discoloration, which creates patches of orange and brown pigmentation.
Diagnosis
With a complete history, the results of a visual examination, and the appropriate laboratory testing aid, a dermatologist can usually determine whether the skin lesions are actually caused by Schamberg's disease.
Schamberg's disease can only be correctly diagnosed by a healthcare provider. For trained skin specialists such as dermatologists, this condition is often easy to diagnose, since the visual appearance of the lesions on the skin itself usually indicates the probability that the cause may be Schamberg's disease. While reviewing a medical history is important for diagnosing this condition, it is important that the purpuric lesions are examined physically.
To ensure that skin lesions are not caused by skin conditions or other infections, doctors will often order a full blood count (CBC) and other blood tests. Blood test results are usually normal. They are done primarily to get rid of other bleeding disorders that cause purpura. Since Schamberg's disease is usually asymptomatic beyond the visible lesion itself, several other tests are usually indicated.
Additional tests may help diagnosis. Skin biopsy can be taken to determine the capillaries of the dermal vessels. Capillaritis or pigmented purpura is a skin condition that has reddish brown spots on the skin, caused by a leaky capillary. Such skin biopsies are sent to the laboratory for pathological examination, in which each biopsy is observed under a microscope. A dermatologist can also perform dermatoscopy.
Treatment and prognosis
There is no cure for Schamberg's disease; However, itching can be controlled by cortisone cream, and Colchicine treatment has been successfully used to prevent recurrence of symptoms. This condition is not life-threatening or a major health problem. The only problem facing the patient is itching and discoloration. It is recommended that patients take vitamin C supplements to promote collagen production, which will help make skin look and feel healthier. To prevent further irritation of the lesions, patients should avoid foods with artificial colors and preservatives. Some people can be allergic to preservatives, which can cause the body to start an allergic reaction by further irritating the lesion. Several studies have shown that Schamberg's disease can be controlled and the number of lesions can be reduced by using a drug called aminaphtone. These drugs help increase capillary fragility and prevent and control purpura lesions.
A patient with Schamberg disease can live a normal and healthy life. Since there is no proven cure for this condition, the patient should bear the lesion on her skin. With proper care, conditions can be better. Although skin lesions are not life-threatening, this can cause cosmetic problems for some individuals. Skin lesions can cause psychological discomfort, where patients may need assurance to help with stress and anxiety. There are several cases of rare T-cell lymphoma that have developed from Schamberg's disease. This is not a cause for concern, since the risk factors associated with Schamberg's disease are relatively low.
Recent research
Some studies of very small non-blind treatment with narrow ultraviolet light have been reported to be promising.
References
External links
Source of the article : Wikipedia
0 Comments